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MLB Rank - Career Strikeouts
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| MLB Rank | Player | SO |
| 1 | Nolan Ryan | 5714 |
| 2 | Steve Carlton | 4136 |
| 3 | Roger Clemens | 3717 |
| 4 | Bert Blyleven | 3701 |
| 5 | Tom Seaver | 3640 |
| 7 | Gaylord Perry | 3534 |
| 8 | Walter Johnson | 3509 |
| 9 | Randy Johnson | 3412 |
| 12 | Bob Gibson | 3117 |
| 15 | Cy Young | 2803 |
| 18 | Warren Spahn | 2583 |
| 19 | Bob Feller | 2581 |
| 21 | Tim Keefe | 2545 |
| 22 | Greg Maddux | 2523 |
| 23 | Christy Mathewson | 2502 |
| 31 | Dennis Eckersley | 2401 |
| 32 | Sandy Koufax | 2396 |
| 34 | Robin Roberts | 2357 |
| 37 | Juan Marichal | 2303 |
| 39 | Lefty Grove | 2266 |
| 42 | Jim Palmer | 2212 |
| 43 | Pete Alexander | 2198 |
| 50 | Dazzy Vance | 2045 |
| 52 | Kevin Brown | 2021 |
| 58 | Pedro Martinez | 1981 |
| 61 | Whitey Ford | 1956 |
| 65 | Amos Rusie | 1934 |
| 68 | Kid Nichols | 1868 |
| 75 | Hal Newhouser | 1796 |
| 82 | Ed Walsh | 1736 |
| 99 | Carl Hubbell | 1677 |
| 118 | Hoyt Wilhelm | 1610 |
| 148 | Rich Gossage | 1502 |
| 186 | Mordecai Brown | 1375 |